OCD Treatment Study: For those Taking Medication but Still Having Symptoms in Philadelphia and New York

This is a study for people who are taking medication for Obsessive Compsulvise Disorder (OCD) but still have trouble with OCD symptoms. The study provides a type of Cognitive Behavioral Therapy for OCD to see whether this therapy can help people become well and then stop taking their medication.

Medication and OCD

The most commonly used treatment for obsessive compulsive disorder (OCD) is a group of medications called serotonin reuptake inhibitors (SRIs). Despite research showing that these medications help many OCD patients, a substantial number who take such medications remain symptomatic. In fact, on average patients taking SRIs experience only a 30% reduction in their OCD symptoms and most have side effects that impact their quality of life.

Another Treatment Option

Another treatment for OCD is a type of cognitive-behavioral therapy called Exposure and Response Prevention (EX/RP). EX/RP has been found effective as a stand-alone treatment for OCD and it can also further reduce OCD symptoms in patients who take medication and continue to experience OCD related distress. Not only is EX/RP effective in reducing symptoms, many patients are able to maintain their gains after therapy has stopped.

Our OCD Treatment Study

The goal of this study is to identify who benefits from adding Exposure and Response Prevention to SRI medication and to find out whether they can discontinue their SRI. Participants in the study will receive up to 25 twice-weekly sessions of EX/RP. Participants who experience a significant reduction of OCD symptoms from EX/RP will be randomly selected to either: 1) gradually discontinue their medication and begin taking a placebo (sugar) pill instead or, 2) to continue taking their medication. Participants will not know if they are taking placebo or medication. All participants will be monitored by the study psychiatrist for an additional 6 months and will receive monthly therapy sessions to help them maintain the gains made from EX/RP.

This study is being conducted in Philadelphia at the University of Pennsylvania and inNew York at Columbia University. To participate in this research, you must be able and willing to travel to either Philadelphia or New York for all study visits.

Click here to find out more about eligibility for our OCD treatment study.

Warning:People with OCD should never try to stop taking their medication without supervision by their prescribing doctor.

Center for the Treatment
and Study of Anxiety
University of Pennsylvania
3535 Market St, 6th Floor
Philadelphia, PA 19104
215-746-3327

EDITED 12/18/14
The contact info for the New York Site has changed:  (646) 774-8062 and the new email is mschwar@nyspi.columbia.edu

Participants Wanted for Mt. Sinai Hospital on Learning How Cognition Works in OCD

Behavioral and fMRI studies of cognition in healthy individuals and patients with anxiety

ID Number 11-1344

Principal Investigator(s) 
Emily Stern 

Department(s) or Division(s) 
Psychiatry 

Description 

The current research study is designed to learn more about how cognition works in individuals with anxiety disorders, specifically Obsessive-Compulsive Disorder (OCD).  This study uses neuroimaging techniques (fMRI) to examine the neural mechanisms underlying switching attention in individuals with a diagnosis of OCD.  

Potential participants may qualify to take part in this research study if they are between the ages of 18 and 50 without a history of serious problems with their health (such as a heart attack), emotions (such as depression) or nervous system (such as seizures), have received a diagnosis of Obsessive-Compulsive Disorder, and are interested in participating in psychological research.

Contact Information 
Alexandra Muratore
(212) 824-8995
sinaibrainlab@mssm.edu 

Recruiting Patients: Yes 

Link http://icahn.mssm.edu/research/clinical-trials/11-1344